Jimmy Suryadi

RESEARCH SUMMARY

My research involves biochemical and biophysical methods for studying the cellular
mechanism of action of a novel platinum–acridine anticancer agent.

• Differentiating the repair mechanisms of the DNA adducts produced by Pt-acridine and the currently used platinum-based anti-tumor drug, cisplatin
  
• Confocal fluorescence spectroscopy study on Pt-acridine uptake and localization in cancer cells using novel conjugation chemistry
  
• X-ray crystallography study of a model DNA duplex containing the monofunctional adduct formed by our prototypical Pt-acridine
  
  

EDUCATION

2011: Ph.D., Department of Chemistry, Wake Forest University, Winston-Salem, NC
2002: Bachelor of Science in Chemistry, Department of Chemistry, Bogor Agricultural University, Indonesia

POSITIONS AND HONORS

2010 – 2011: Teaching Assistant, Wake Forest University, Winston-Salem, North Carolina, USA
2005 – 2009: Research Asistant, Wake Forest University, Winston-Salem, North Carolina, USA
2003 – 2004: Teaching Assistant, Wake Forest University, Winston-Salem, North Carolina, USA
2002 – 2003: Inorganic Chemistry Teaching Assistant, Chemistry Department, Bogor Agricultural University, Bogor, Indonesia

PEER-REVIEWED PUBLICATIONS

S. Ding, X. Qiao, J. Suryadi, G. S. Marrs, G. L. Kucera, U. Bierbach: Using Fluorescent Post-Labeling To Probe the Subcellular Localization of DNA-Targeted Platinum Anticancer Agents. Angewandte Chemie, 52, 3350-3354. (2013)

J. Suryadi, U. Bierbach: DNA Metalating-Intercalating Hybrid Agents for the Treatment of Chemoresistant Cancers. Chemistry - A European Journal, 18, 12926-12934. (2012)

L. A. Graham, J. Suryadi, T. K. West, G. L. Kucera, U. Bierbach: Synthesis, Aqueous Reactivity, and Biological Evalulation of Carboxylic Acid Ester-Functionalized Platinum-Acridine Hybrid Anticancer Agents. Journal of Medicinal Chemistry, 55, 7817-7827. (2012)

Suryadi, J., Tran, E. J., Maxwell, E. S., Brown, B. A., 2nd. The crystal structure of the Methanocaldococcus jannaschii multifunctional L7Ae RNA-binding protein reveals an induced-fit interaction with the box C/D RNAs. Biochemistry 2005, 44, (28), 9657-72.

Gagnon, K. T., Zhang, X., Qu, G., Biswas, S., Suryadi, J., Brown, B. A., 2nd., Maxwell, E. S. Signature amino acids enable the archaeal L7Ae box C/D RNP core protein to recognize and bind the K-loop RNA motif. RNA 16, (1), 79-90.

CONFERENCE PRESENTATIONS

Jimmy Suryadi and Rebecca W. Alexander. Pre-steady State Kinetics and Unnatural Amino Acid Fluorescence on tRNA Synthetase. SERMACS 2009. San Juan, Puerto Rico. October 21 – 24, 2009 and Research Triangle Park, NC. October 16 – 17, 2009.

Jimmy Suryadi and Rebecca W. Alexander. Fluorescence Changes upon Substrate Binding to an Aminoacyl-tRNA Synthetase. SERMACS 2008. Nashville, TN. November 12 – 15, 2008.

Jimmy Suryadi and Rebecca W. Alexander. Hydrogen/Deuterium Exchange Revealed Unprecedented Information of MetRS upon tRNAfMet Binding. The North Carolina RNA Society Symposium. University of North Carolina. October 19 – 20, 2007.

Jimmy Suryadi and Bernard A. Brown II. Contributions of L7Ae Loop 9 Residues to RNA-Binding Specificity. Gordon Research Conference on Nucleic Acids, Salve Regina University Newport, RI. June 5 – 10, 2005.

Jimmy Suryadi, Theodore Gupton, and Bernard A. Brown II. Structural Analyses of L7Ae-box C/D RNA Interactions. SERMACS 2004. Research Triangle Park, NC. November 10 – 13, 2004.